Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage

Mitochondrial dysfunction is interconnected with cancer. Nevertheless, how defective mitochondria promote cancer is poorly understood. We find that mitochondrial dysfunction promotes DNA damage under conditions of increased apoptotic priming. Underlying this process, we reveal a key role for mitocho...

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Detalles Bibliográficos
Autores principales: Cao, Kai, Riley, Joel S., Heilig, Rosalie, Montes-Gómez, Alfredo E., Vringer, Esmee, Berthenet, Kevin, Cloix, Catherine, Elmasry, Yassmin, Spiller, David G., Ichim, Gabriel, Campbell, Kirsteen J., Gilmore, Andrew P., Tait, Stephen W.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616799/
https://www.ncbi.nlm.nih.gov/pubmed/35447090
http://dx.doi.org/10.1016/j.devcel.2022.03.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616799/
https://www.ncbi.nlm.nih.gov/pubmed/35447090
http://dx.doi.org/10.1016/j.devcel.2022.03.019

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