Overlapping gene dependencies for PARP inhibitors and carboplatin response identified by functional CRISPR-Cas9 screening in ovarian cancer

PARP inhibitors (PARPi) have revolutionized the therapeutic landscape of epithelial ovarian cancer (EOC) treatment with outstanding benefits in regard to progression-free survival, especially in patients either carrying BRCA1/2 mutations or harboring defects in the homologous recombination repair sy...

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Detalles Bibliográficos
Autores principales: Coelho, Ricardo, Tozzi, Alessandra, Disler, Muriel, Lombardo, Flavio, Fedier, André, López, Mónica Núñez, Freuler, Florian, Jacob, Francis, Heinzelmann-Schwarz, Viola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616819/
https://www.ncbi.nlm.nih.gov/pubmed/36307400
http://dx.doi.org/10.1038/s41419-022-05347-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616819/
https://www.ncbi.nlm.nih.gov/pubmed/36307400
http://dx.doi.org/10.1038/s41419-022-05347-x

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