Combinatorial gene targeting in primary human hematopoietic stem and progenitor cells

The CRISPR/Cas9 system offers enormous versatility for functional genomics but many applications have proven to be challenging in primary human cells compared to cell lines or mouse cells. Here, to establish a paradigm for multiplexed gene editing in primary human cord blood-derived hematopoietic st...

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Detalles Bibliográficos
Autores principales: Bäckström, Alexandra, Yudovich, David, Žemaitis, Kristijonas, Nilsén Falck, Ludvig, Subramaniam, Agatheeswaran, Larsson, Jonas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616885/
https://www.ncbi.nlm.nih.gov/pubmed/36307542
http://dx.doi.org/10.1038/s41598-022-23118-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616885/
https://www.ncbi.nlm.nih.gov/pubmed/36307542
http://dx.doi.org/10.1038/s41598-022-23118-8

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