Senolytic treatment rescues blunted muscle hypertrophy in old mice

With aging, skeletal muscle plasticity is attenuated in response to exercise. Here, we report that senescent cells, identified using senescence-associated β-galactosidase (SA β-Gal) activity and p21 immunohistochemistry, are very infrequent in resting muscle, but emerge approximately 2 weeks after a...

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Detalles Bibliográficos
Autores principales: Dungan, Cory M., Figueiredo, Vandre C., Wen, Yuan, VonLehmden, Georgia L., Zdunek, Christopher J., Thomas, Nicholas T., Mobley, C. Brooks, Murach, Kevin A., Brightwell, Camille R., Long, Douglas E., Fry, Christopher S., Kern, Philip A., McCarthy, John J., Peterson, Charlotte A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616988/
https://www.ncbi.nlm.nih.gov/pubmed/35325353
http://dx.doi.org/10.1007/s11357-022-00542-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616988/
https://www.ncbi.nlm.nih.gov/pubmed/35325353
http://dx.doi.org/10.1007/s11357-022-00542-2

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