Ancient Origins of Allosteric Activation in a Ser/Thr Kinase

Despite a myriad of cellular events being regulated by allostery, evolution of this process is largely unexplored territory. Here, we use Ancestral Sequence Reconstruction (ASR) to resurrect ancestors of two colocalizing proteins, Aurora A kinase and its allosteric activator TPX2, to experimentally...

Descripción completa

Detalles Bibliográficos
Autores principales: Hadzipasic, Adelajda, Wilson, Christopher, Nguyen, Vy, Kern, Nadja, Kim, Chansik, Pitsawong, Warintra, Villali, Janice, Zheng, Yuejiao, Kern, Dorothee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617290/
https://www.ncbi.nlm.nih.gov/pubmed/32079772
http://dx.doi.org/10.1126/science.aay9959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617290/
https://www.ncbi.nlm.nih.gov/pubmed/32079772
http://dx.doi.org/10.1126/science.aay9959

Ejemplares similares