Cargando…

Ancient Origins of Allosteric Activation in a Ser/Thr Kinase

Despite a myriad of cellular events being regulated by allostery, evolution of this process is largely unexplored territory. Here, we use Ancestral Sequence Reconstruction (ASR) to resurrect ancestors of two colocalizing proteins, Aurora A kinase and its allosteric activator TPX2, to experimentally...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hadzipasic, Adelajda, Wilson, Christopher, Nguyen, Vy, Kern, Nadja, Kim, Chansik, Pitsawong, Warintra, Villali, Janice, Zheng, Yuejiao, Kern, Dorothee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617290/ https://www.ncbi.nlm.nih.gov/pubmed/32079772 http://dx.doi.org/10.1126/science.aay9959

Ejemplares similares

A biophysical framework for double-drugging kinases
por: Kim, Chansik, et al.
Publicado: (2023)

Dynamics of human protein kinase Aurora A linked to drug selectivity
por: Pitsawong, Warintra, et al.
Publicado: (2018)

Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2
por: Zorba, Adelajda, et al.
Publicado: (2014)

Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2
por: Pádua, Ricardo A. P., et al.
Publicado: (2018)

From primordial clocks to circadian oscillators
por: Pitsawong, Warintra, et al.
Publicado: (2023)

Probing Microsecond Time Scale Dynamics in Proteins by Methyl (1)H Carr−Purcell−Meiboom−Gill Relaxation Dispersion NMR Measurements. Application to Activation of the Signaling Protein NtrC(r)
por: Otten, Renee, et al.
Publicado: (2010)

How directed evolution reshapes energy landscapes in enzymes to boost catalysis
por: Otten, Renee, et al.
Publicado: (2020)

Diversity in domain architectures of Ser/Thr kinases and their homologues in prokaryotes
por: Krupa, A, et al.
Publicado: (2005)

Analysis of Ser/Thr Kinase HASPIN-Interacting Proteins in the Spermatids
por: Maeda, Naoko, et al.
Publicado: (2022)

Cellular Ser/Thr-Kinase Assays Using Generic Peptide Substrates
por: Adams, Deanna G, et al.
Publicado: (2008)

Natural Compounds and Derivatives as Ser/Thr Protein Kinase Modulators and Inhibitors
por: Guerra, Barbara, et al.
Publicado: (2019)

Bacterial Cell Division Regulation by Ser/Thr Kinases: A Structural Perspective
por: Ruggiero, Alessia, et al.
Publicado: (2012)

Autophosphorylation Mechanism of the Ser/Thr Kinase Stk1 From Staphylococcus aureus
por: Zheng, Weihao, et al.
Publicado: (2018)

In-Depth Characterization of the Clostridioides difficile Phosphoproteome to Identify Ser/Thr Kinase Substrates
por: Garcia-Garcia, Transito, et al.
Publicado: (2022)

FIKK Kinase, a Ser/Thr Kinase Important to Malaria Parasites, Is Inhibited by Tyrosine Kinase Inhibitors
por: Lin, Benjamin C., et al.
Publicado: (2017)

A biophysical framework for double-drugging kinases
por: Kim, C., et al.
Publicado: (2023)

Mycobacterium tuberculosis Ser/Thr Protein Kinase B Mediates an Oxygen-Dependent Replication Switch
por: Ortega, Corrie, et al.
Publicado: (2014)

Ser/Thr kinase Trc controls neurite outgrowth in Drosophila by modulating microtubule-microtubule sliding
por: Norkett, Rosalind, et al.
Publicado: (2020)

Molecular Basis for Ser/Thr Specificity in PKA Signaling
por: Knape, Matthias J., et al.
Publicado: (2020)

Coordinated Expression of Tristetraprolin Post-Transcriptionally Attenuates Mitogenic Induction of the Oncogenic Ser/Thr Kinase Pim-1
por: Mahat, Dig B., et al.
Publicado: (2012)

Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase
por: Shlevkov, Evgeny, et al.
Publicado: (2021)

Informing Efforts to Develop Nitroreductase for Amine Production
por: Miller, Anne-Frances, et al.
Publicado: (2018)

M. tuberculosis Ser/Thr Protein Kinase D Phosphorylates an Anti-Anti–Sigma Factor Homolog
por: Greenstein, Andrew E, et al.
Publicado: (2007)

Deciphering the Arginine-Binding Preferences at the Substrate-Binding Groove of Ser/Thr Kinases by Computational Surface Mapping
por: Ben-Shimon, Avraham, et al.
Publicado: (2011)

Functional analysis of the BRI1 receptor kinase by Thr-for-Ser substitution in a regulatory autophosphorylation site
por: Oh, Man-Ho, et al.
Publicado: (2015)

Search for Potent and Selective Aurora A Inhibitors Based on General Ser/Thr Kinase Pharmacophore Model
por: Vasilevich, Natalya I., et al.
Publicado: (2016)

Mycobacterium tuberculosis Thymidylyltransferase RmlA Is Negatively Regulated by Ser/Thr Protein Kinase PknB
por: Qu, Dehui, et al.
Publicado: (2021)

Ser/Thr protein phosphatases in fungi: structure, regulation and function
por: Ariño, Joaquín, et al.
Publicado: (2019)

Phosphorylation of Ribosomal Protein S6 Kinase 1 at Thr421/Ser424 and Dephosphorylation at Thr389 Regulates SP600125-Induced Polyploidization of Megakaryocytic Cell Lines
por: Li, Chang-Ling, et al.
Publicado: (2014)

Massive Autophosphorylation of the Ser/Thr-Rich Domain Controls Protein Kinase Activity of TRPM6 and TRPM7
por: Clark, Kristopher, et al.
Publicado: (2008)

Ser/Thr Kinase-Like Protein of Nicotiana benthamiana Is Involved in the Cell-to-Cell Movement of Bamboo mosaic virus
por: Cheng, Shun-Fang, et al.
Publicado: (2013)

Impacts of Ser/Thr Protein Kinase Stk1 on the Proteome, Twitching Motility, and Competitive Advantage in Pseudomonas aeruginosa
por: Zhu, Xuan, et al.
Publicado: (2021)

DHCR24 Knock-Down Induced Tau Hyperphosphorylation at Thr181, Ser199, Thr231, Ser262, Ser396 Epitopes and Inhibition of Autophagy by Overactivation of GSK3β/mTOR Signaling
por: Bai, Xiaojing, et al.
Publicado: (2021)

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR(B) GTPase domain
por: Malik, Asad U., et al.
Publicado: (2022)

Thioredoxin-family protein EYE2 and Ser/Thr kinase EYE3 play interdependent roles in eyespot assembly
por: Boyd, Joseph S., et al.
Publicado: (2011)

Eukaryotic-Type Ser/Thr Protein Kinase Mediated Phosphorylation of Mycobacterial Phosphodiesterase Affects its Localization to the Cell Wall
por: Malhotra, Neha, et al.
Publicado: (2016)

Streptococcus suis DivIVA Protein Is a Substrate of Ser/Thr Kinase STK and Involved in Cell Division Regulation
por: Ni, Hua, et al.
Publicado: (2018)

The Ser/Thr Kinase PknH Is Essential for Maintaining Heterocyst Pattern in the Cyanobacterium Anabaena sp. Strain PCC 7120
por: Fukushima, Shun-ichi, et al.
Publicado: (2018)

Ser/Thr protein kinase PrkC-mediated regulation of GroEL is critical for biofilm formation in Bacillus anthracis
por: Arora, Gunjan, et al.
Publicado: (2017)

Identification of Ser/Thr kinase and Forkhead Associated Domains in Mycobacterium ulcerans: Characterization of Novel Association between Protein Kinase Q and MupFHA
por: Arora, Gunjan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ohc69qq9ls7plpuijqi380ajcn