ATM kinase inhibitor AZD0156 in combination with irinotecan and 5-fluorouracil in preclinical models of colorectal cancer

BACKGROUND: AZD0156 is an oral inhibitor of ATM, a serine threonine kinase that plays a key role in DNA damage response (DDR) associated with double-strand breaks. Topoisomerase-I inhibitor irinotecan is used clinically to treat colorectal cancer (CRC), often in combination with 5-fluorouracil (5FU)...

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Detalles Bibliográficos
Autores principales: Davis, S. Lindsey, Hartman, Sarah J., Bagby, Stacey M., Schlaepfer, Marina, Yacob, Betelehem W., Tse, Tonia, Simmons, Dennis M., Diamond, Jennifer R., Lieu, Christopher H., Leal, Alexis D., Cadogan, Elaine B., Hughes, Gareth D., Durant, Stephen T., Messersmith, Wells A., Pitts, Todd M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617348/
https://www.ncbi.nlm.nih.gov/pubmed/36309653
http://dx.doi.org/10.1186/s12885-022-10084-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617348/
https://www.ncbi.nlm.nih.gov/pubmed/36309653
http://dx.doi.org/10.1186/s12885-022-10084-7

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