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HDAC6 Inhibition Reverses Cisplatin-Induced Mechanical Hypersensitivity via Tonic Delta Opioid Receptor Signaling
Peripheral neuropathic pain induced by the chemotherapeutic cisplatin can persist for months to years after treatment. Histone deacetylase 6 (HDAC6) inhibitors have therapeutic potential for cisplatin-induced neuropathic pain since they persistently reverse mechanical hypersensitivity and spontaneou...
Autores principales: | Zhang, Jixiang, Junigan, Jazzmine M., Trinh, Ronnie, Kavelaars, Annemieke, Heijnen, Cobi J., Grace, Peter M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617617/ https://www.ncbi.nlm.nih.gov/pubmed/36096670 http://dx.doi.org/10.1523/JNEUROSCI.1182-22.2022 |
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