CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma

Melanoma is the deadliest form of skin cancer and considered intrinsically resistant to chemotherapy. Nearly all melanomas harbor mutations that activate the RAS/mitogen-activated protein kinase (MAPK) pathway, which contributes to drug resistance via poorly described mechanisms. Herein we show that...

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Detalles Bibliográficos
Autores principales: Houles, Thibault, Lavoie, Geneviève, Nourreddine, Sami, Cheung, Winnie, Vaillancourt-Jean, Éric, Guérin, Célia M., Bouttier, Mathieu, Grondin, Benoit, Lin, Sichun, Saba-El-Leil, Marc K., Angers, Stephane, Meloche, Sylvain, Roux, Philippe P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617877/
https://www.ncbi.nlm.nih.gov/pubmed/36309522
http://dx.doi.org/10.1038/s41467-022-34179-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617877/
https://www.ncbi.nlm.nih.gov/pubmed/36309522
http://dx.doi.org/10.1038/s41467-022-34179-8

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