A novel BH3 mimetic Bcl-2 inhibitor promotes autophagic cell death and reduces in vivo Glioblastoma tumor growth

Anti-apoptotic members of the Bcl-2 family proteins play central roles in the regulation of cell death in glioblastoma (GBM), the most malignant type of brain tumor. Despite the advances in GBM treatment, there is still an urgent need for new therapeutic approaches. Here, we report a novel 4-thiazol...

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Detalles Bibliográficos
Autores principales: Calis, Seyma, Dogan, Berna, Durdagi, Serdar, Celebi, Asuman, Yapicier, Ozlem, Kilic, Turker, Turanli, Eda Tahir, Avsar, Timucin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617882/
https://www.ncbi.nlm.nih.gov/pubmed/36309485
http://dx.doi.org/10.1038/s41420-022-01225-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617882/
https://www.ncbi.nlm.nih.gov/pubmed/36309485
http://dx.doi.org/10.1038/s41420-022-01225-9

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