G(i/o) protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na(+)/K(+) ATPase activation

G(i/o)-coupled somatostatin or α2-adrenergic receptor activation stimulated β-cell NKA activity, resulting in islet Ca(2+) fluctuations. Furthermore, intra-islet paracrine activation of β-cell G(i/o)-GPCRs and NKAs by δ-cell somatostatin secretion slowed Ca(2+) oscillations, which decreased insulin...

Descripción completa

Detalles Bibliográficos
Autores principales: Dickerson, Matthew T., Dadi, Prasanna K., Zaborska, Karolina E., Nakhe, Arya Y., Schaub, Charles M., Dobson, Jordyn R., Wright, Nicole M., Lynch, Joshua C., Scott, Claire F., Robinson, Logan D., Jacobson, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617941/
https://www.ncbi.nlm.nih.gov/pubmed/36309517
http://dx.doi.org/10.1038/s41467-022-34166-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617941/
https://www.ncbi.nlm.nih.gov/pubmed/36309517
http://dx.doi.org/10.1038/s41467-022-34166-z

Ejemplares similares