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G(i/o) protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na(+)/K(+) ATPase activation
G(i/o)-coupled somatostatin or α2-adrenergic receptor activation stimulated β-cell NKA activity, resulting in islet Ca(2+) fluctuations. Furthermore, intra-islet paracrine activation of β-cell G(i/o)-GPCRs and NKAs by δ-cell somatostatin secretion slowed Ca(2+) oscillations, which decreased insulin...
Autores principales: | Dickerson, Matthew T., Dadi, Prasanna K., Zaborska, Karolina E., Nakhe, Arya Y., Schaub, Charles M., Dobson, Jordyn R., Wright, Nicole M., Lynch, Joshua C., Scott, Claire F., Robinson, Logan D., Jacobson, David A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617941/ https://www.ncbi.nlm.nih.gov/pubmed/36309517 http://dx.doi.org/10.1038/s41467-022-34166-z |
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