Mendelian randomization accounting for complex correlated horizontal pleiotropy while elucidating shared genetic etiology

Mendelian randomization (MR) harnesses genetic variants as instrumental variables (IVs) to study the causal effect of exposure on outcome using summary statistics from genome-wide association studies. Classic MR assumptions are violated when IVs are associated with unmeasured confounders, i.e., when...

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Detalles Bibliográficos
Autores principales: Cheng, Qing, Zhang, Xiao, Chen, Lin S., Liu, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618026/
https://www.ncbi.nlm.nih.gov/pubmed/36310177
http://dx.doi.org/10.1038/s41467-022-34164-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618026/
https://www.ncbi.nlm.nih.gov/pubmed/36310177
http://dx.doi.org/10.1038/s41467-022-34164-1

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