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Mendelian randomization accounting for complex correlated horizontal pleiotropy while elucidating shared genetic etiology
Mendelian randomization (MR) harnesses genetic variants as instrumental variables (IVs) to study the causal effect of exposure on outcome using summary statistics from genome-wide association studies. Classic MR assumptions are violated when IVs are associated with unmeasured confounders, i.e., when...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618026/ https://www.ncbi.nlm.nih.gov/pubmed/36310177 http://dx.doi.org/10.1038/s41467-022-34164-1 |