UBR2 targets myosin heavy chain IIb and IIx for degradation: Molecular mechanism essential for cancer-induced muscle wasting

Cancer cachexia is a lethal metabolic syndrome featuring muscle wasting with preferential loss of fast-twitching muscle mass through an undefined mechanism. Here, we show that cancer induces muscle wasting by selectively degrading myosin heavy chain (MHC) subtypes IIb and IIx through E3 ligase UBR2-...

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Detalles Bibliográficos
Autores principales: Gao, Song, Zhang, Guohua, Zhang, Zicheng, Zhu, James Z., Li, Li, Zhou, Yong, Rodney, George G., Abo-Zahrah, Reem S., Anderson, Lindsey, Garcia, Jose M., Kwon, Yong Tae, Li, Yi-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618047/
https://www.ncbi.nlm.nih.gov/pubmed/36252004
http://dx.doi.org/10.1073/pnas.2200215119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618047/
https://www.ncbi.nlm.nih.gov/pubmed/36252004
http://dx.doi.org/10.1073/pnas.2200215119

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