TGM2-mediated histone transglutamination is dictated by steric accessibility

Recent studies have identified serotonylation of glutamine-5 on histone H3 (H3Q5ser) as a novel posttranslational modification (PTM) associated with active transcription. While H3Q5ser is known to be installed by tissue transglutaminase 2 (TGM2), the substrate characteristics affecting deposition of...

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Detalles Bibliográficos
Autores principales: Lukasak, Bradley J., Mitchener, Michelle M., Kong, Lingchun, Dul, Barbara E., Lazarus, Cole D., Ramakrishnan, Aarthi, Ni, Jizhi, Shen, Li, Maze, Ian, Muir, Tom W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618071/
https://www.ncbi.nlm.nih.gov/pubmed/36256821
http://dx.doi.org/10.1073/pnas.2208672119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618071/
https://www.ncbi.nlm.nih.gov/pubmed/36256821
http://dx.doi.org/10.1073/pnas.2208672119

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