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The ulcerative colitis-associated gene FUT8 regulates the quantity and quality of secreted mucins
Mucins are the main macrocomponents of the mucus layer that protects the digestive tract from pathogens. Fucosylation of mucins increases mucus viscoelasticity and its resistance to shear stress. These properties are altered in patients with ulcerative colitis (UC), which is marked by a chronic infl...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618082/ https://www.ncbi.nlm.nih.gov/pubmed/36252012 http://dx.doi.org/10.1073/pnas.2205277119 |