Endocytosis triggers V-ATPase-SYK–mediated priming of cGAS activation and innate immune response

The current view of nucleic acid–mediated innate immunity is that binding of intracellular sensors to nucleic acids is sufficient for their activation. Here, we report that endocytosis of virus or foreign DNA initiates a priming signal for the DNA sensor cyclic GMP-AMP synthase (cGAS)–mediated innat...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Yu-Lin, Cao, Li-Bo, He, Wen-Rui, Zhong, Li, Guo, Yi, Yang, Qing, Shu, Hong-Bing, Hu, Ming-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618142/
https://www.ncbi.nlm.nih.gov/pubmed/36252040
http://dx.doi.org/10.1073/pnas.2207280119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618142/
https://www.ncbi.nlm.nih.gov/pubmed/36252040
http://dx.doi.org/10.1073/pnas.2207280119

Ejemplares similares