Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex

Increasing evidence suggests synaptic dysfunction is a central and possibly triggering factor in Amyotrophic Lateral Sclerosis (ALS). Despite this, we still know very little about the molecular profile of an ALS synapse. To address this gap, we designed a synaptic proteomics experiment to perform an...

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Detalles Bibliográficos
Autores principales: Laszlo, Zsofia I., Hindley, Nicole, Sanchez Avila, Anna, Kline, Rachel A., Eaton, Samantha L., Lamont, Douglas J., Smith, Colin, Spires-Jones, Tara L., Wishart, Thomas M., Henstridge, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618182/
https://www.ncbi.nlm.nih.gov/pubmed/36309735
http://dx.doi.org/10.1186/s40478-022-01455-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618182/
https://www.ncbi.nlm.nih.gov/pubmed/36309735
http://dx.doi.org/10.1186/s40478-022-01455-z

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