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MED12 mutation as a potential predictive biomarker for immune checkpoint inhibitors in pan-cancer
Immune checkpoint inhibitors (ICIs) therapy elicits admirable anti-tumor responses across many types of cancer. Growing evidence point to a link to Mediator complex subunit 12 (MED12) and DNA damage repair (DDR) and TGF-β signing, while the clinical data on the association of MED12 and ICIs response...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618186/ https://www.ncbi.nlm.nih.gov/pubmed/36309740 http://dx.doi.org/10.1186/s40001-022-00856-z |