Cargando…

An optimized exosome production strategy for enhanced yield while without sacrificing cargo loading efficiency

BACKGROUND: Exosome mediated mRNA delivery is a promising strategy for the treatment of multiple diseases. However, the low yield of exosomes is a bottleneck for clinical translation. In this study, we boosted exosome production via simultaneously reducing the expression of genes inhibiting exosome...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Rongxin, Bu, Te, Cao, Ruidan, Li, Zhelong, Wang, Chen, Huang, Bing, Wei, Mengying, Yuan, Lijun, Yang, Guodong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618217/ https://www.ncbi.nlm.nih.gov/pubmed/36309712 http://dx.doi.org/10.1186/s12951-022-01668-3

Ejemplares similares

Exosome-mediated delivery of inflammation-responsive Il-10 mRNA for controlled atherosclerosis treatment
por: Bu, Te, et al.
Publicado: (2021)

Establishment of an Efficient Genome Editing System in Lettuce Without Sacrificing Specificity
por: Pan, Wenbo, et al.
Publicado: (2022)

Efficient exosome delivery in refractory tissues assisted by ultrasound-targeted microbubble destruction
por: Sun, Wenqi, et al.
Publicado: (2019)

Ultrasound triggered topical delivery of Bmp7 mRNA for white fat browning induction via engineered smart exosomes
por: Guo, Yitong, et al.
Publicado: (2021)

Sacrificed Lives
Publicado: (1869)

Optimizing Porcine Islet Isolation to Markedly Reduce Enzyme Consumption Without Sacrificing Islet Yield or Function
por: Holdcraft, Robert W., et al.
Publicado: (2016)

Passive radiant cooling without sacrificing the aesthetics of objects
por: Dereń, Przemysław Jacek
Publicado: (2022)

The dilemma for lipid productivity in green microalgae: importance of substrate provision in improving oil yield without sacrificing growth
por: Tan, Kenneth Wei Min, et al.
Publicado: (2016)

Current Strategies for Exosome Cargo Loading and Targeting Delivery
por: Zeng, Haifeng, et al.
Publicado: (2023)

Tentacle probes: eliminating false positives without sacrificing sensitivity
por: Satterfield, Brent C., et al.
Publicado: (2007)

Enabling Genomic-Phenomic Association Discovery without Sacrificing Anonymity
por: Heatherly, Raymond D., et al.
Publicado: (2013)

Implementation science: Relevance in the real world without sacrificing rigor
por: Geng, Elvin H., et al.
Publicado: (2017)

Cortactin enhances exosome secretion without altering cargo
por: Gangoda, Lahiru, et al.
Publicado: (2016)

Improved extracellular vesicle-based mRNA delivery for familial hypercholesterolemia treatment
por: Yang, Zheng, et al.
Publicado: (2023)

Correction: Enabling Genomic-Phenomic Association Discovery without Sacrificing Anonymity
por: Heatherly, Raymond D., et al.
Publicado: (2013)

Fusion protein engineered exosomes for targeted degradation of specific RNAs in lysosomes: a proof-of-concept study
por: Li, Zhelong, et al.
Publicado: (2020)

Are self-sacrificing employees liked by their supervisor?
por: Bande, Belén, et al.
Publicado: (2023)

Digitalising medical education: sacrificing skills for knowledge?
por: Ranasinghe, Lasith
Publicado: (2019)

The Pandemic of Publications: Are We Sacrificing Quality for Quantity?
por: Martins, Russell Seth, et al.
Publicado: (2020)

The Requisiteness for not Sacrificing Medical Biotechnology in the Coronavirus Era
por: Akhondzadeh, Shahin, et al.
Publicado: (2021)

Targeted elimination of senescent cells by engineered extracellular vesicles attenuates atherosclerosis in ApoE(-/-) mice with minimal side effects
por: Zhang, Liang, et al.
Publicado: (2023)

Brown adipose tissue-derived exosomes mitigate the metabolic syndrome in high fat diet mice
por: Zhou, Xueying, et al.
Publicado: (2020)

Regulation of exosome production and cargo sorting
por: Wei, Hong, et al.
Publicado: (2021)

ARAG, an Antioxidant-Rich Gel, Shows Superiority to Mepilex Ag in the Treatment of Deep Partial Thickness Burns without Sacrificing Antimicrobial Efficiency
por: Cartwright, Brian Michael, et al.
Publicado: (2023)

Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model
por: Li, Zhelong, et al.
Publicado: (2021)

Abstract 14: Improving Autonomy Without Sacrificing Safety—the Value of a Resident Aesthetic Clinic
por: Shakir, Sameer, et al.
Publicado: (2019)

A simple strategy to enhance the speed of protein secondary structure prediction without sacrificing accuracy
por: Juan, Sheng-Hung, et al.
Publicado: (2020)

A tribute to frontline corona warriors––Doctors who sacrificed their life while saving patients during the ongoing COVID-19 pandemic
por: Pandey, Suresh K, et al.
Publicado: (2020)

Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets
por: Wang, Chen, et al.
Publicado: (2021)

Chondroitin sulfate proteoglycan serglycin influences protein cargo loading and functions of tumor-derived exosomes
por: Purushothaman, Anurag, et al.
Publicado: (2017)

Sacrificed: Ontario Healthcare Workers in the Time of COVID-19
por: Brophy, James T., et al.
Publicado: (2020)

Engineering a disulfide-gated switch in streptavidin enables reversible binding without sacrificing binding affinity
por: Marangoni, Jesse M., et al.
Publicado: (2020)

Chronic myelogenous leukemia cells remodel the bone marrow niche via exosome-mediated transfer of miR-320
por: Gao, Xiaotong, et al.
Publicado: (2019)

Multifaceted Roles of Adipose Tissue-Derived Exosomes in Physiological and Pathological Conditions
por: Liu, Yunnan, et al.
Publicado: (2021)

The poor homology stringency in the heteroduplex allows strand exchange to incorporate desirable mismatches without sacrificing recognition in vivo
por: Danilowicz, Claudia, et al.
Publicado: (2015)

AutoPEWS: Automating Pediatric Early Warning Score Calculation Improves Accuracy Without Sacrificing Predictive Ability
por: Lockwood, Justin M, et al.
Publicado: (2020)

V/Q SPECT/CT in the Time of COVID-19: Changing the Order to Improve Safety Without Sacrificing Accuracy
por: Schaefer, Wolfgang M., et al.
Publicado: (2021)

Reduced dose of PTCy followed by adjuvant α-galactosylceramide enhances GVL effect without sacrificing GVHD suppression
por: Nakamura, Makoto, et al.
Publicado: (2021)

Facilitating open science without sacrificing IP rights: A novel tool for improving replicability of published research
por: Cohen‐Sasson, Or, et al.
Publicado: (2022)

Could Fluvoxamine Dose De-escalation Increase Treatment Compliance Without Sacrificing Efficacy in COVID-19 Patients?
por: Marcec, Robert, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vb03pa2b55mfrmc4d41vvch83q