Topoisomerase 3b is dispensable for replication of a positive-sense RNA virus--murine coronavirus

A recent study demonstrated that a DNA-RNA dual-activity topoisomerase complex, TOP3B-TDRD3, is required for normal replication of positive-sense RNA viruses, including several human flaviviruses and coronaviruses; and the authors proposed that TOP3B is a target of antiviral drugs. Here we examined...

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Detalles Bibliográficos
Autores principales: Zhang, Tianyi, Su, Shuaikun, Altouma, Valerie, Zhu, Xingliang, Xue, Yutong, Shen, Weiping, Wilgenburg, Brian, Wang, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618458/
https://www.ncbi.nlm.nih.gov/pubmed/36328071
http://dx.doi.org/10.1016/j.antiviral.2022.105451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618458/
https://www.ncbi.nlm.nih.gov/pubmed/36328071
http://dx.doi.org/10.1016/j.antiviral.2022.105451

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