Specific properties of shRNA-mediated CCR5 downregulation that enhance the inhibition of HIV-1 infection in combination with shRNA targeting HIV-1 rev

Treatment with RNAi against HIV-1 transcripts efficiently inhibits viral replication but induces selection of escape mutants; therefore, the CCR5 coreceptor was suggested as an additional target. Blocking viral and host transcripts improved the antiviral effect. We have used short hairpin RNA (shRNA...

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Detalles Bibliográficos
Autores principales: Cardona, Maria E., Hinkula, Jorma, Gustafsson, Kristin, Christensson, Birger, Wahren, Britta, Mohamed, Abdalla J., Smith, C. I. Edvard, Arteaga, H. Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618491/
https://www.ncbi.nlm.nih.gov/pubmed/36098885
http://dx.doi.org/10.1007/s11033-022-07899-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618491/
https://www.ncbi.nlm.nih.gov/pubmed/36098885
http://dx.doi.org/10.1007/s11033-022-07899-9

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