Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures

Activation of insulin receptor (IR) initiates a cascade of conformational changes and autophosphorylation events. Herein, we determined three structures of IR trapped by aptamers using cryo-electron microscopy. The A62 agonist aptamer selectively activates metabolic signaling. In the absence of insu...

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Detalles Bibliográficos
Autores principales: Kim, Junhong, Yunn, Na-Oh, Park, Mangeun, Kim, Jihan, Park, Seongeun, Kim, Yoojoong, Noh, Jeongeun, Ryu, Sung Ho, Cho, Yunje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618554/
https://www.ncbi.nlm.nih.gov/pubmed/36310231
http://dx.doi.org/10.1038/s41467-022-34292-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618554/
https://www.ncbi.nlm.nih.gov/pubmed/36310231
http://dx.doi.org/10.1038/s41467-022-34292-8

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