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Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures
Activation of insulin receptor (IR) initiates a cascade of conformational changes and autophosphorylation events. Herein, we determined three structures of IR trapped by aptamers using cryo-electron microscopy. The A62 agonist aptamer selectively activates metabolic signaling. In the absence of insu...
Autores principales: | Kim, Junhong, Yunn, Na-Oh, Park, Mangeun, Kim, Jihan, Park, Seongeun, Kim, Yoojoong, Noh, Jeongeun, Ryu, Sung Ho, Cho, Yunje |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618554/ https://www.ncbi.nlm.nih.gov/pubmed/36310231 http://dx.doi.org/10.1038/s41467-022-34292-8 |
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