Advances in biomaterials as a retinal patch for the repair of rhegmatogenous retinal detachment
Rhegmatogenous retinal detachment (RRD) is the most common retinological emergency that can cause blindness without surgical treatment. RRD occurs when liquefied vitreous accumulates between the neurosensory retina and the retinal pigment epithelium via retinal breaks, which are caused by the separa...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618627/ https://www.ncbi.nlm.nih.gov/pubmed/36324894 http://dx.doi.org/10.3389/fbioe.2022.997243 |
_version_ | 1784821092173479936 |
---|---|
author | Zheng, Chuanzhen Wen, Dejia Xu, Kejia Zhang, Xiaomin Ren, Xinjun Li, Xiaorong |
author_facet | Zheng, Chuanzhen Wen, Dejia Xu, Kejia Zhang, Xiaomin Ren, Xinjun Li, Xiaorong |
author_sort | Zheng, Chuanzhen |
collection | PubMed |
description | Rhegmatogenous retinal detachment (RRD) is the most common retinological emergency that can cause blindness without surgical treatment. RRD occurs when liquefied vitreous accumulates between the neurosensory retina and the retinal pigment epithelium via retinal breaks, which are caused by the separation of the vitreous from the retina with aging. Currently, the main treatment option is pars plana vitrectomy, which involves surgical removal of the vitreous and laser photocoagulation around retinal breaks to generate firm chorioretinal adhesion, as well as subsequent filling of the vitreous cavity with long-lasting substitutes (expansile gas or silocone oil) to prevent the connection between the subretinal space and the vitreous cavity via the breaks before the chorioretinal adhesion firm enough. However, the postoperative face-down position and the not very satisfactory first retinal reattachment rate place a heavy burden on patients. With the development of technology and materials engineering, researchers have developed biomaterials that can be used as a retinal patch to seal retinal breaks and prevent the connection of subretinal space and vitreous cavity via breaks, thus replacing the long-lasting vitreous substitutes and eliminating the postoperative face-down position. Preclinical studies have demonstrated that biomaterial sealants have enough biocompatibility and efficacy in the in vitro and in vivo experiments. Some sealants have been used in clinical trials on a small scale, and the results indicate promising application prospects of the biomaterial sealants as retinal patches in the repair of RRD. Herein, we review the recent advances in biomaterials as retinal patches for the repair of RRD, focusing on the biomaterial categories, methods, and procedures for sealing retinal breaks, as well as their biocompatibility and efficacy, current limitations, and development perspectives. |
format | Online Article Text |
id | pubmed-9618627 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96186272022-11-01 Advances in biomaterials as a retinal patch for the repair of rhegmatogenous retinal detachment Zheng, Chuanzhen Wen, Dejia Xu, Kejia Zhang, Xiaomin Ren, Xinjun Li, Xiaorong Front Bioeng Biotechnol Bioengineering and Biotechnology Rhegmatogenous retinal detachment (RRD) is the most common retinological emergency that can cause blindness without surgical treatment. RRD occurs when liquefied vitreous accumulates between the neurosensory retina and the retinal pigment epithelium via retinal breaks, which are caused by the separation of the vitreous from the retina with aging. Currently, the main treatment option is pars plana vitrectomy, which involves surgical removal of the vitreous and laser photocoagulation around retinal breaks to generate firm chorioretinal adhesion, as well as subsequent filling of the vitreous cavity with long-lasting substitutes (expansile gas or silocone oil) to prevent the connection between the subretinal space and the vitreous cavity via the breaks before the chorioretinal adhesion firm enough. However, the postoperative face-down position and the not very satisfactory first retinal reattachment rate place a heavy burden on patients. With the development of technology and materials engineering, researchers have developed biomaterials that can be used as a retinal patch to seal retinal breaks and prevent the connection of subretinal space and vitreous cavity via breaks, thus replacing the long-lasting vitreous substitutes and eliminating the postoperative face-down position. Preclinical studies have demonstrated that biomaterial sealants have enough biocompatibility and efficacy in the in vitro and in vivo experiments. Some sealants have been used in clinical trials on a small scale, and the results indicate promising application prospects of the biomaterial sealants as retinal patches in the repair of RRD. Herein, we review the recent advances in biomaterials as retinal patches for the repair of RRD, focusing on the biomaterial categories, methods, and procedures for sealing retinal breaks, as well as their biocompatibility and efficacy, current limitations, and development perspectives. Frontiers Media S.A. 2022-10-17 /pmc/articles/PMC9618627/ /pubmed/36324894 http://dx.doi.org/10.3389/fbioe.2022.997243 Text en Copyright © 2022 Zheng, Wen, Xu, Zhang, Ren and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Zheng, Chuanzhen Wen, Dejia Xu, Kejia Zhang, Xiaomin Ren, Xinjun Li, Xiaorong Advances in biomaterials as a retinal patch for the repair of rhegmatogenous retinal detachment |
title | Advances in biomaterials as a retinal patch for the repair of rhegmatogenous retinal detachment |
title_full | Advances in biomaterials as a retinal patch for the repair of rhegmatogenous retinal detachment |
title_fullStr | Advances in biomaterials as a retinal patch for the repair of rhegmatogenous retinal detachment |
title_full_unstemmed | Advances in biomaterials as a retinal patch for the repair of rhegmatogenous retinal detachment |
title_short | Advances in biomaterials as a retinal patch for the repair of rhegmatogenous retinal detachment |
title_sort | advances in biomaterials as a retinal patch for the repair of rhegmatogenous retinal detachment |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618627/ https://www.ncbi.nlm.nih.gov/pubmed/36324894 http://dx.doi.org/10.3389/fbioe.2022.997243 |
work_keys_str_mv | AT zhengchuanzhen advancesinbiomaterialsasaretinalpatchfortherepairofrhegmatogenousretinaldetachment AT wendejia advancesinbiomaterialsasaretinalpatchfortherepairofrhegmatogenousretinaldetachment AT xukejia advancesinbiomaterialsasaretinalpatchfortherepairofrhegmatogenousretinaldetachment AT zhangxiaomin advancesinbiomaterialsasaretinalpatchfortherepairofrhegmatogenousretinaldetachment AT renxinjun advancesinbiomaterialsasaretinalpatchfortherepairofrhegmatogenousretinaldetachment AT lixiaorong advancesinbiomaterialsasaretinalpatchfortherepairofrhegmatogenousretinaldetachment |