Advances in biomaterials as a retinal patch for the repair of rhegmatogenous retinal detachment

Rhegmatogenous retinal detachment (RRD) is the most common retinological emergency that can cause blindness without surgical treatment. RRD occurs when liquefied vitreous accumulates between the neurosensory retina and the retinal pigment epithelium via retinal breaks, which are caused by the separa...

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Autores principales: Zheng, Chuanzhen, Wen, Dejia, Xu, Kejia, Zhang, Xiaomin, Ren, Xinjun, Li, Xiaorong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618627/
https://www.ncbi.nlm.nih.gov/pubmed/36324894
http://dx.doi.org/10.3389/fbioe.2022.997243
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author Zheng, Chuanzhen
Wen, Dejia
Xu, Kejia
Zhang, Xiaomin
Ren, Xinjun
Li, Xiaorong
author_facet Zheng, Chuanzhen
Wen, Dejia
Xu, Kejia
Zhang, Xiaomin
Ren, Xinjun
Li, Xiaorong
author_sort Zheng, Chuanzhen
collection PubMed
description Rhegmatogenous retinal detachment (RRD) is the most common retinological emergency that can cause blindness without surgical treatment. RRD occurs when liquefied vitreous accumulates between the neurosensory retina and the retinal pigment epithelium via retinal breaks, which are caused by the separation of the vitreous from the retina with aging. Currently, the main treatment option is pars plana vitrectomy, which involves surgical removal of the vitreous and laser photocoagulation around retinal breaks to generate firm chorioretinal adhesion, as well as subsequent filling of the vitreous cavity with long-lasting substitutes (expansile gas or silocone oil) to prevent the connection between the subretinal space and the vitreous cavity via the breaks before the chorioretinal adhesion firm enough. However, the postoperative face-down position and the not very satisfactory first retinal reattachment rate place a heavy burden on patients. With the development of technology and materials engineering, researchers have developed biomaterials that can be used as a retinal patch to seal retinal breaks and prevent the connection of subretinal space and vitreous cavity via breaks, thus replacing the long-lasting vitreous substitutes and eliminating the postoperative face-down position. Preclinical studies have demonstrated that biomaterial sealants have enough biocompatibility and efficacy in the in vitro and in vivo experiments. Some sealants have been used in clinical trials on a small scale, and the results indicate promising application prospects of the biomaterial sealants as retinal patches in the repair of RRD. Herein, we review the recent advances in biomaterials as retinal patches for the repair of RRD, focusing on the biomaterial categories, methods, and procedures for sealing retinal breaks, as well as their biocompatibility and efficacy, current limitations, and development perspectives.
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spelling pubmed-96186272022-11-01 Advances in biomaterials as a retinal patch for the repair of rhegmatogenous retinal detachment Zheng, Chuanzhen Wen, Dejia Xu, Kejia Zhang, Xiaomin Ren, Xinjun Li, Xiaorong Front Bioeng Biotechnol Bioengineering and Biotechnology Rhegmatogenous retinal detachment (RRD) is the most common retinological emergency that can cause blindness without surgical treatment. RRD occurs when liquefied vitreous accumulates between the neurosensory retina and the retinal pigment epithelium via retinal breaks, which are caused by the separation of the vitreous from the retina with aging. Currently, the main treatment option is pars plana vitrectomy, which involves surgical removal of the vitreous and laser photocoagulation around retinal breaks to generate firm chorioretinal adhesion, as well as subsequent filling of the vitreous cavity with long-lasting substitutes (expansile gas or silocone oil) to prevent the connection between the subretinal space and the vitreous cavity via the breaks before the chorioretinal adhesion firm enough. However, the postoperative face-down position and the not very satisfactory first retinal reattachment rate place a heavy burden on patients. With the development of technology and materials engineering, researchers have developed biomaterials that can be used as a retinal patch to seal retinal breaks and prevent the connection of subretinal space and vitreous cavity via breaks, thus replacing the long-lasting vitreous substitutes and eliminating the postoperative face-down position. Preclinical studies have demonstrated that biomaterial sealants have enough biocompatibility and efficacy in the in vitro and in vivo experiments. Some sealants have been used in clinical trials on a small scale, and the results indicate promising application prospects of the biomaterial sealants as retinal patches in the repair of RRD. Herein, we review the recent advances in biomaterials as retinal patches for the repair of RRD, focusing on the biomaterial categories, methods, and procedures for sealing retinal breaks, as well as their biocompatibility and efficacy, current limitations, and development perspectives. Frontiers Media S.A. 2022-10-17 /pmc/articles/PMC9618627/ /pubmed/36324894 http://dx.doi.org/10.3389/fbioe.2022.997243 Text en Copyright © 2022 Zheng, Wen, Xu, Zhang, Ren and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Zheng, Chuanzhen
Wen, Dejia
Xu, Kejia
Zhang, Xiaomin
Ren, Xinjun
Li, Xiaorong
Advances in biomaterials as a retinal patch for the repair of rhegmatogenous retinal detachment
title Advances in biomaterials as a retinal patch for the repair of rhegmatogenous retinal detachment
title_full Advances in biomaterials as a retinal patch for the repair of rhegmatogenous retinal detachment
title_fullStr Advances in biomaterials as a retinal patch for the repair of rhegmatogenous retinal detachment
title_full_unstemmed Advances in biomaterials as a retinal patch for the repair of rhegmatogenous retinal detachment
title_short Advances in biomaterials as a retinal patch for the repair of rhegmatogenous retinal detachment
title_sort advances in biomaterials as a retinal patch for the repair of rhegmatogenous retinal detachment
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618627/
https://www.ncbi.nlm.nih.gov/pubmed/36324894
http://dx.doi.org/10.3389/fbioe.2022.997243
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