Engineering human spinal microphysiological systems to model opioid-induced tolerance

pioids are commonly used for treating chronic pain. However, with continued use, they may induce tolerance and/or hyperalgesia, which limits therapeutic efficacy. The human mechanisms of opioid-induced tolerance and hyperalgesia are significantly understudied, in part, because current models cannot...

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Detalles Bibliográficos
Autores principales: Cai, Hongwei, Ao, Zheng, Tian, Chunhui, Wu, Zhuhao, Kaurich, Connor, Chen, Zi, Gu, Mingxia, Hohmann, Andrea G., Mackie, Ken, Guo, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618681/
https://www.ncbi.nlm.nih.gov/pubmed/36330161
http://dx.doi.org/10.1016/j.bioactmat.2022.10.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618681/
https://www.ncbi.nlm.nih.gov/pubmed/36330161
http://dx.doi.org/10.1016/j.bioactmat.2022.10.007

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