Physical confinement promotes mesenchymal trans-differentiation of invading transformed cells in vivo

Metastasis is tightly linked with poor cancer prognosis, yet it is not clear how transformed cells become invasive carcinomas. We previously discovered that single KRas(V12)-transformed cells can invade directly from the epithelium by basal cell extrusion. During this process, cells de-differentiate...

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Detalles Bibliográficos
Autores principales: Zulueta-Coarasa, Teresa, Fadul, John, Ahmed, Marjana, Rosenblatt, Jody
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618776/
https://www.ncbi.nlm.nih.gov/pubmed/36325066
http://dx.doi.org/10.1016/j.isci.2022.105330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618776/
https://www.ncbi.nlm.nih.gov/pubmed/36325066
http://dx.doi.org/10.1016/j.isci.2022.105330

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