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The affinity of antigen-binding domain on the antitumor efficacy of CAR T cells: Moderate is better
The overall efficacy of chimeric antigen receptor modified T cells (CARTs) remain limited in solid tumors despite intensive studies that aim at targeting multiple antigens, enhancing migration, reducing tonic signaling, and improving tumor microenvironment. On the other hand, how the affinity and en...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618871/ https://www.ncbi.nlm.nih.gov/pubmed/36325345 http://dx.doi.org/10.3389/fimmu.2022.1032403 |