Zn(2+) inhibits spatial memory and hippocampal place cell representation through high-affinity binding to the NMDA receptor GluN2A subunit

A subset of glutamatergic neurons in the forebrain uses labile Zn(2+) as a co-transmitter alongside glutamate. Synaptic Zn(2+) plays a key role in learning and memory processes, but its mechanisms of action remain poorly understood. Here, we used a knock-in (KI) mouse line carrying a point mutation...

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Detalles Bibliográficos
Autores principales: Sikora, Joanna, Di Bisceglie Caballero, Sonia, Reiss, David, Kieffer, Brigitte L., Paoletti, Pierre, Jacob, Pierre-Yves, Ouagazzal, Abdel-Mouttalib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619178/
https://www.ncbi.nlm.nih.gov/pubmed/36325055
http://dx.doi.org/10.1016/j.isci.2022.105355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619178/
https://www.ncbi.nlm.nih.gov/pubmed/36325055
http://dx.doi.org/10.1016/j.isci.2022.105355

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