De novo serine biosynthesis from glucose predicts sex-specific response to antifolates in non-small cell lung cancer cell lines

Lung cancer is the leading cause of cancer-related death. Intriguingly, males with non-small cell lung cancer (NSCLC) have a higher mortality rate than females. Here, we investigated the role of serine metabolism as a predictive marker for sensitivity to the antifolate pemetrexed in male and female...

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Detalles Bibliográficos
Autores principales: Sponagel, Jasmin, Devarakonda, Siddhartha, Rubin, Joshua B., Luo, Jingqin, Ippolito, Joseph E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619300/
https://www.ncbi.nlm.nih.gov/pubmed/36325067
http://dx.doi.org/10.1016/j.isci.2022.105339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619300/
https://www.ncbi.nlm.nih.gov/pubmed/36325067
http://dx.doi.org/10.1016/j.isci.2022.105339

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