Integrative epigenomic analyses of small cell lung cancer cells demonstrates the clinical translational relevance of gene body methylation

DNA methylation is a key regulator of gene expression and a clinical therapeutic predictor. We examined global DNA methylation beyond the generally used promoter areas in human small cell lung cancer (SCLC) and find that gene body methylation is a robust positive predictor of gene expression. Combin...

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Detalles Bibliográficos
Autores principales: Pongor, Lorinc S., Tlemsani, Camille, Elloumi, Fathi, Arakawa, Yasuhiro, Jo, Ukhyun, Gross, Jacob M., Mosavarpour, Sara, Varma, Sudhir, Kollipara, Rahul K., Roper, Nitin, Teicher, Beverly A., Aladjem, Mirit I., Reinhold, William, Thomas, Anish, Minna, John D., Johnson, Jane E., Pommier, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619308/
https://www.ncbi.nlm.nih.gov/pubmed/36325065
http://dx.doi.org/10.1016/j.isci.2022.105338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619308/
https://www.ncbi.nlm.nih.gov/pubmed/36325065
http://dx.doi.org/10.1016/j.isci.2022.105338

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