Ebola and Marburg virus VP35 coiled-coil validated as antiviral target by tripartite split-GFP complementation

Ebola virus (EBOV) and Marburg virus (MARV) are highly pathogenic viruses in humans, against which approved antivirals are lacking. During EBOV and MARV infection, coiled-coil mediated oligomerization is essential for the virion protein 35 (VP35) polymerase co-factor function and type I interferon a...

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Detalles Bibliográficos
Autores principales: Zinzula, Luca, Mereu, Angela Maria, Orsini, Massimiliano, Seeleitner, Christine, Bracher, Andreas, Nagy, István, Baumeister, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619376/
https://www.ncbi.nlm.nih.gov/pubmed/36325051
http://dx.doi.org/10.1016/j.isci.2022.105354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619376/
https://www.ncbi.nlm.nih.gov/pubmed/36325051
http://dx.doi.org/10.1016/j.isci.2022.105354

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