Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1

Trace metals are essential for various physiological processes, but their roles in innate immunity have not been fully explored. Here, we found that manganese (Mn) significantly enhanced DNA-mediated IFN-α, IFN-β, and IFN-λ1 production. Microarray analysis demonstrated Mn highly upregulated 351 gene...

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Detalles Bibliográficos
Autores principales: Sui, Hongyan, Chen, Qian, Yang, Jun, Srirattanapirom, Selena, Imamichi, Tomozumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619380/
https://www.ncbi.nlm.nih.gov/pubmed/36325059
http://dx.doi.org/10.1016/j.isci.2022.105352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619380/
https://www.ncbi.nlm.nih.gov/pubmed/36325059
http://dx.doi.org/10.1016/j.isci.2022.105352

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