Discovery of a Novel Potent Antitumor Molecule, P19G1, by Erlotinib Derivative Libraries Synthesized by Modular Click-Chemistry

Objective:Traditional chemical synthesis methods are cumbersome and inefficient. In this study, a novel antitumor molecule, 4-(4-(3-((6,7-bis(2-methoxyethoxy)quinazolin-4-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)phenyl sulfurofluoridate (P19G1), was identified by screening a library of Erlotinib deriv...

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Detalles Bibliográficos
Autores principales: Cui, Qianfei, Song, Peng, Ma, Tiancheng, Wang, Zefeng, Lu, Xiaojing, Shi, Yongjia, Zhang, Fang, Lin, Guoqiang, Dong, Jiajia, Zhang, Jiange
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Novel Small Molecules Used for Cancer Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619925/
https://www.ncbi.nlm.nih.gov/pubmed/36303409
http://dx.doi.org/10.1177/15330338221109649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619925/
https://www.ncbi.nlm.nih.gov/pubmed/36303409
http://dx.doi.org/10.1177/15330338221109649

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