Novel Efficient Multistage Lead Optimization Pipeline Experimentally Validated for DYRK1B Selective Inhibitors

[Image: see text] In addition to general challenges in drug discovery such as the identification of lead compounds in time- and cost-effective ways, specific challenges also exist. Particularly, it is necessary to develop pharmacological inhibitors that effectively discriminate between closely relat...

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Detalles Bibliográficos
Autores principales: Alexandrov, Vadim, Vilenchik, Maria, Kantidze, Omar, Tsutskiridze, Nika, Kharchilava, Daviti, Lhewa, Pema, Shishkin, Aleksandr, Gankin, Yuriy, Kirpich, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619999/
https://www.ncbi.nlm.nih.gov/pubmed/36239428
http://dx.doi.org/10.1021/acs.jmedchem.2c00988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9619999/
https://www.ncbi.nlm.nih.gov/pubmed/36239428
http://dx.doi.org/10.1021/acs.jmedchem.2c00988

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