Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential Oral On-Demand Treatment for Hereditary Angioedema

[Image: see text] Hereditary angioedema (HAE) is a rare genetic disorder in which patients experience sudden onset of swelling in various locations of the body. HAE is associated with uncontrolled plasma kallikrein (PKa) enzyme activity and generation of the potent inflammatory mediator, bradykinin,...

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Detalles Bibliográficos
Autores principales: Davie, Rebecca L., Edwards, Hannah J., Evans, D. Michael, Hodgson, Simon T., Stocks, Michael J., Smith, Alun J., Rushbrooke, Louise J., Pethen, Stephen J., Roe, Michael B., Clark, David E., McEwan, Paul A., Hampton, Sally L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620001/
https://www.ncbi.nlm.nih.gov/pubmed/36251573
http://dx.doi.org/10.1021/acs.jmedchem.2c00921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620001/
https://www.ncbi.nlm.nih.gov/pubmed/36251573
http://dx.doi.org/10.1021/acs.jmedchem.2c00921

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