Targeting Aggrecanases for Osteoarthritis Therapy: From Zinc Chelation to Exosite Inhibition

[Image: see text] Osteoarthritis (OA) is the most common degenerative joint disease. In 1999, two members of the A Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) family of metalloproteinases, ADAMTS4 and ADAMTS5, or aggrecanases, were identified as the enzymes responsible for...

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Detalles Bibliográficos
Autores principales: Cuffaro, Doretta, Ciccone, Lidia, Rossello, Armando, Nuti, Elisa, Santamaria, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620172/
https://www.ncbi.nlm.nih.gov/pubmed/36250680
http://dx.doi.org/10.1021/acs.jmedchem.2c01177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620172/
https://www.ncbi.nlm.nih.gov/pubmed/36250680
http://dx.doi.org/10.1021/acs.jmedchem.2c01177

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