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Targeting Aggrecanases for Osteoarthritis Therapy: From Zinc Chelation to Exosite Inhibition
[Image: see text] Osteoarthritis (OA) is the most common degenerative joint disease. In 1999, two members of the A Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) family of metalloproteinases, ADAMTS4 and ADAMTS5, or aggrecanases, were identified as the enzymes responsible for...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620172/ https://www.ncbi.nlm.nih.gov/pubmed/36250680 http://dx.doi.org/10.1021/acs.jmedchem.2c01177 |