Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists

[Image: see text] Cyclic dinucleotides (CDNs) are second messengers that activate stimulator of interferon genes (STING). The cGAS-STING pathway plays a promising role in cancer immunotherapy. Here, we describe the synthesis of CDNs containing 7-substituted 7-deazapurine moiety. We used mouse cyclic...

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Detalles Bibliográficos
Autores principales: Vavřina, Zdeněk, Perlíková, Pavla, Milisavljević, Nemanja, Chevrier, Florian, Smola, Miroslav, Smith, Joshua, Dejmek, Milan, Havlíček, Vojtěch, Buděšínský, Miloš, Liboska, Radek, Vaneková, Lenka, Brynda, Jiří, Boura, Evzen, Řezáčová, Pavlína, Hocek, Michal, Birkuš, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620234/
https://www.ncbi.nlm.nih.gov/pubmed/36201304
http://dx.doi.org/10.1021/acs.jmedchem.2c01305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620234/
https://www.ncbi.nlm.nih.gov/pubmed/36201304
http://dx.doi.org/10.1021/acs.jmedchem.2c01305

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