Dopamine D2 receptors bidirectionally regulate striatal enkephalin expression: Implications for cocaine reward

Low dopamine D2 receptor (D2R) availability in the striatum can predispose for cocaine abuse; though how low striatal D2Rs facilitate cocaine reward is unclear. Overexpression of D2Rs in striatal neurons or activation of D2Rs by acute cocaine suppresses striatal Penk mRNA. Conversely, low D2Rs in D2...

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Detalles Bibliográficos
Autores principales: Dai, Kathy Z., Choi, In Bae, Levitt, Ryan, Blegen, Mariah B., Kaplan, Alanna R., Matsui, Aya, Shin, J. Hoon, Bocarsly, Miriam E., Simpson, Eleanor H., Kellendonk, Christoph, Alvarez, Veronica A., Dobbs, Lauren K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620395/
https://www.ncbi.nlm.nih.gov/pubmed/36170833
http://dx.doi.org/10.1016/j.celrep.2022.111440

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