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Loss of T cell tolerance in the skin following immunopathology is linked to failed restoration of the dermal niche by recruited macrophages

T cell pathology in the skin leads to monocyte influx, but we have little understanding of the fate of recruited cells within the diseased niche, or the long-term impact on cutaneous immune homeostasis. By combining a murine model of acute graft-versus-host disease (aGVHD) with analysis of patient s...

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Detalles Bibliográficos
Autores principales: West, Heather C., Davies, James, Henderson, Stephen, Adegun, Oluyori K., Ward, Sophie, Ferrer, Ivana R., Tye, Chanidapa A., Vallejo, Andres F., Jardine, Laura, Collin, Matthew, Polak, Marta E., Bennett, Clare L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620741/
https://www.ncbi.nlm.nih.gov/pubmed/35584681
http://dx.doi.org/10.1016/j.celrep.2022.110819