The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling

Defects in primary cilia, cellular antennas that control multiple intracellular signaling pathways, underlie several neurodevelopmental disorders, but it remains unknown how cilia control essential steps in human brain formation. Here, we show that cilia are present on the apical surface of radial g...

Descripción completa

Detalles Bibliográficos
Autores principales: Schembs, Leah, Willems, Ariane, Hasenpusch-Theil, Kerstin, Cooper, James D., Whiting, Katie, Burr, Karen, Bøstrand, Sunniva M.K., Selvaraj, Bhuvaneish T., Chandran, Siddharthan, Theil, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620745/
https://www.ncbi.nlm.nih.gov/pubmed/35584663
http://dx.doi.org/10.1016/j.celrep.2022.110811

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620745/
https://www.ncbi.nlm.nih.gov/pubmed/35584663
http://dx.doi.org/10.1016/j.celrep.2022.110811

Ejemplares similares