Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms

Detection of host cell protein (HCP) impurities is critical to ensuring that recombinant drug products, including monoclonal antibodies (mAbs), are safe. Mechanistic characterization as to how HCPs persist in drug products is important to refining downstream processing. It has been hypothesized that...

Descripción completa

Detalles Bibliográficos
Autores principales: Hecht, Elizabeth Sara, Mehta, Shrenik, Wecksler, Aaron T., Aguilar, Ben, Swanson, Nathaniel, Phung, Wilson, Dubey Kelsoe, Ananya, Benner, W. Henry, Tesar, Devin, Kelley, Robert F., Sandoval, Wendy, Sreedhara, Alavattam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621051/
https://www.ncbi.nlm.nih.gov/pubmed/36284469
http://dx.doi.org/10.1080/19420862.2022.2135183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621051/
https://www.ncbi.nlm.nih.gov/pubmed/36284469
http://dx.doi.org/10.1080/19420862.2022.2135183

Ejemplares similares