Mutant Samd9l expression impairs hematopoiesis and induces bone marrow failure in mice

SAMD9 and SAMD9L germline mutations have recently emerged as a new class of predispositions to pediatric myeloid neoplasms. Patients commonly have impaired hematopoiesis, hypocellular marrows, and a greater risk of developing clonal chromosome 7 deletions leading to MDS and AML. We recently demonstr...

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Detalles Bibliográficos
Autores principales: Abdelhamed, Sherif, Thomas, Melvin E., Westover, Tamara, Umeda, Masayuki, Xiong, Emily, Rolle, Chandra, Walsh, Michael P., Wu, Huiyun, Schwartz, Jason R., Valentine, Virginia, Valentine, Marcus, Pounds, Stanley, Ma, Jing, Janke, Laura J., Klco, Jeffery M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621136/
https://www.ncbi.nlm.nih.gov/pubmed/36074606
http://dx.doi.org/10.1172/JCI158869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621136/
https://www.ncbi.nlm.nih.gov/pubmed/36074606
http://dx.doi.org/10.1172/JCI158869

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