Immune dysfunction signatures predict outcomes and define checkpoint blockade–unresponsive microenvironments in acute myeloid leukemia

BACKGROUND: Immune exhaustion and senescence are dominant dysfunctional states of effector T cells and major hurdles for the success of cancer immunotherapy. In the current study, we characterized how acute myeloid leukemia (AML) promotes the generation of senescent-like CD8(+) T cells and whether t...

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Detalles Bibliográficos
Autores principales: Rutella, Sergio, Vadakekolathu, Jayakumar, Mazziotta, Francesco, Reeder, Stephen, Yau, Tung-On, Mukhopadhyay, Rupkatha, Dickins, Benjamin, Altmann, Heidi, Kramer, Michael, Knaus, Hanna A., Blazar, Bruce R., Radojcic, Vedran, Zeidner, Joshua F., Arruda, Andrea, Wang, Bofei, Abbas, Hussein A., Minden, Mark D., Tasian, Sarah K., Bornhäuser, Martin, Gojo, Ivana, Luznik, Leo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621145/
https://www.ncbi.nlm.nih.gov/pubmed/36099049
http://dx.doi.org/10.1172/JCI159579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621145/
https://www.ncbi.nlm.nih.gov/pubmed/36099049
http://dx.doi.org/10.1172/JCI159579

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