Cargando…

Immune dysfunction signatures predict outcomes and define checkpoint blockade–unresponsive microenvironments in acute myeloid leukemia

BACKGROUND: Immune exhaustion and senescence are dominant dysfunctional states of effector T cells and major hurdles for the success of cancer immunotherapy. In the current study, we characterized how acute myeloid leukemia (AML) promotes the generation of senescent-like CD8(+) T cells and whether t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rutella, Sergio, Vadakekolathu, Jayakumar, Mazziotta, Francesco, Reeder, Stephen, Yau, Tung-On, Mukhopadhyay, Rupkatha, Dickins, Benjamin, Altmann, Heidi, Kramer, Michael, Knaus, Hanna A., Blazar, Bruce R., Radojcic, Vedran, Zeidner, Joshua F., Arruda, Andrea, Wang, Bofei, Abbas, Hussein A., Minden, Mark D., Tasian, Sarah K., Bornhäuser, Martin, Gojo, Ivana, Luznik, Leo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Clinical Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621145/ https://www.ncbi.nlm.nih.gov/pubmed/36099049 http://dx.doi.org/10.1172/JCI159579

Ejemplares similares

Hyperactive neutrophil chemotaxis contributes to anti‐tumor necrosis factor‐α treatment resistance in inflammatory bowel disease
por: Yau, Tung On, et al.
Publicado: (2022)

T-Cell Manipulation Strategies to Prevent Graft-Versus-Host Disease in Haploidentical Stem Cell Transplantation
por: Vadakekolathu, Jayakumar, et al.
Publicado: (2017)

Targeting Leukemia Stem Cells in the Bone Marrow Niche
por: Tasian, Sarah K., et al.
Publicado: (2018)

Induction of T-cell mitogenic unresponsiveness by recombinant human granulocyte colony-stimulating factor (rHuG-CSF)
por: Rutella, S, et al.
Publicado: (2000)

Treatment of AML Relapse After Allo-HCT
por: Webster, Jonathan A., et al.
Publicado: (2021)

S129: ADOPTIVELY INFUSED MEMORY-LIKE (ML) NATURAL KILLER (NK) CELLS ELICIT ADAPTIVE IMMUNE RESPONSES IN PATIENTS WITH ACUTE MYELOID LEUKEMIA (AML)
por: Rutella, Sergio, et al.
Publicado: (2023)

Immune-Phenotyping and Transcriptomic Profiling of Peripheral Blood Mononuclear Cells From Patients With Breast Cancer: Identification of a 3 Gene Signature Which Predicts Relapse of Triple Negative Breast Cancer
por: Foulds, Gemma A., et al.
Publicado: (2018)

Loss of the Mismatched Human Leukocyte Antigen Haplotype in Two Acute Myelogenous Leukemia Relapses after Haploidentical Bone Marrow Transplantation with Posttransplantation Cyclophosphamide
por: McCurdy, Shannon R., et al.
Publicado: (2016)

Flow cytometry and targeted immune transcriptomics identify distinct profiles in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors with or without interferon-α
por: Alves, Raquel, et al.
Publicado: (2020)

Transfer of specific unresponsiveness to organ allografts by thymocytes. Specific unresponsiveness by thymocyte transfer
Publicado: (1979)

Gene Expression Profiling of FFPE Samples: A Titration Test
por: Manjunath, Harshitha Shobha, et al.
Publicado: (2022)

Methylene blue unresponsive methemoglobinemia
por: Patnaik, Sibabratta, et al.
Publicado: (2014)

Golimumab in unresponsive ulcerative colitis
por: Lippert, Elisabeth, et al.
Publicado: (2014)

Methylene blue unresponsive methemoglobinemia
por: Mirakbari, Seyed Mostafa
Publicado: (2014)

An unresponsive COVID-19 patient
por: Nepal, Pankaj, et al.
Publicado: (2020)

A novel spontaneous model of epithelial-mesenchymal transition (EMT) using a primary prostate cancer derived cell line demonstrating distinct stem-like characteristics
por: Harner-Foreman, Naomi, et al.
Publicado: (2017)

A Novel HAGE/WT1-ImmunoBody(®) Vaccine Combination Enhances Anti-Tumour Responses When Compared to Either Vaccine Alone
por: Almshayakhchi, Rukaia, et al.
Publicado: (2021)

IMMUNOLOGIC UNRESPONSIVENESS INDUCED BY PROTEIN ANTIGENS
por: Dixon, Frank J., et al.
Publicado: (1955)

Overcoming immune-cell unresponsiveness in cancer
por: Lametschwandtner, Guenther, et al.
Publicado: (2013)

Intracranial pressure in unresponsive chronic migraine
por: De Simone, Roberto, et al.
Publicado: (2014)

Strategies to Overcome Antileishmanial Drugs Unresponsiveness
por: Sundar, Shyam, et al.
Publicado: (2014)

Unresponsive Intractable Chronic Headache With Sitagliptin
por: Zaghloul, Ahmed, et al.
Publicado: (2018)

Esophageal Crohn's Disease Unresponsive to Glucocorticoids
por: Kochar, Tanureet, et al.
Publicado: (2019)

Comments on unresponsive decompression illness case
por: Mirasoglu, Bengusu, et al.
Publicado: (2018)

Immunobiology of Steroid-Unresponsive Severe Asthma
por: Marshall, Courtney Lynn, et al.
Publicado: (2021)

Immunological unresponsiveness to thymus-independent antigens: two fundamentally different genetic mechanisms of B-cell unresponsiveness to dextran
por: Fernandez, C, et al.
Publicado: (1977)

Restoration of IFNγR Subunit Assembly, IFNγ Signaling and Parasite Clearance in Leishmania donovani Infected Macrophages: Role of Membrane Cholesterol
por: Sen, Subha, et al.
Publicado: (2011)

Once BCG Unresponsive, Always BCG Unresponsive: An Open Letter to the FDA to Enhance Recruitment into Clinical Trials in Bladder Cancer
por: Kamat, Ashish M., et al.
Publicado: (2017)

A Mutated Prostatic Acid Phosphatase (PAP) Peptide-Based Vaccine Induces PAP-Specific CD8(+) T Cells with Ex Vivo Cytotoxic Capacities in HHDII/DR1 Transgenic Mice
por: Vu, Pauline Le, et al.
Publicado: (2022)

Induction and abrogation of unresponsiveness in nude mouse cells
Publicado: (1976)

Plasma exchange for steroid unresponsive Devic's disease
por: Devi, B. V., et al.
Publicado: (2012)

Breaking tolerance to pancreatic cancer unresponsiveness to chemotherapy
por: Ramakrishna, B. S.
Publicado: (2021)

Atypical Presentation of Boerhaave Syndrome With Hypoxia and Unresponsiveness
por: Bury, Jordan, et al.
Publicado: (2022)

STUDIES ON THE INDUCTION OF IMMUNOLOGICAL UNRESPONSIVENESS TO PNEUMOCOCCAL POLYSACCHARIDE IN MICE
por: Siskind, Gregory W., et al.
Publicado: (1966)

FATE OF ANTIGEN-BINDING CELLS IN UNRESPONSIVE AND IMMUNE MICE
por: Louis, J., et al.
Publicado: (1973)

THE SPECIFICITY OF ALLERGIC REACTIONS : VI. UNRESPONSIVENESS TO SIMPLE CHEMICALS
por: Coe, John E., et al.
Publicado: (1963)

Brain processing of pain in patients with unresponsive wakefulness syndrome
por: Markl, Alexandra, et al.
Publicado: (2013)

Calcium Unresponsive Hypocalcemic Tetany: Gitelman Syndrome with Hypocalcemia
por: Desai, Madhav, et al.
Publicado: (2013)

Dronabinol for chemotherapy-induced nausea and vomiting unresponsive to antiemetics
por: May, Megan Brafford, et al.
Publicado: (2016)

Across the consciousness continuum—from unresponsive wakefulness to sleep
por: Blume, Christine, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_vs126rf5iciov7nrko45rkv23h