Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation

BACKGROUND: The loss of tumor antigens and depletion of CD8 T cells caused by the PD-1/PD-L1 pathway are important factors for tumor immune escape. In recent years, there has been increasing research on traditional Chinese medicine in tumor treatment. Cycloastragenol (CAG), an effective active molec...

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Detalles Bibliográficos
Autores principales: Deng, Guoliang, Zhou, Lisha, Wang, Binglin, Sun, Xiaofan, Zhang, Qinchang, Chen, Hongqi, Wan, Ning, Ye, Hui, Wu, Xiaoqi, Sun, Dongdong, Sun, Yang, Cheng, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621195/
https://www.ncbi.nlm.nih.gov/pubmed/36307151
http://dx.doi.org/10.1136/jitc-2022-004874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621195/
https://www.ncbi.nlm.nih.gov/pubmed/36307151
http://dx.doi.org/10.1136/jitc-2022-004874

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