Cargando…

MERS-CoV nsp1 regulates autophagic flux via mTOR signalling and dysfunctional lysosomes

Autophagy, a cellular surveillance mechanism, plays an important role in combating invading pathogens. However, viruses have evolved various strategies to disrupt autophagy and even hijack it for replication and release. Here, we demonstrated that Middle East respiratory syndrome coronavirus (MERS-C...

Descripción completa

Detalles Bibliográficos
Autores principales:	Feng, Yujie, Pan, Zhaoyi, Wang, Zhihui, Lei, Zhengyang, Yang, Songge, Zhao, Huajun, Wang, Xueyao, Yu, Yating, Han, Qiuju, Zhang, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Coronaviruses
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621213/ https://www.ncbi.nlm.nih.gov/pubmed/36153658 http://dx.doi.org/10.1080/22221751.2022.2128434

Ejemplares similares

MERS-CoV nsp1 impairs the cellular metabolic processes by selectively downregulating mRNAs in a novel granules
por: Pan, Zhaoyi, et al.
Publicado: (2022)

Ubiquilins Regulate Autophagic Flux through mTOR Signaling and Lysosomal Acidification
por: Şentürk, Mümine, et al.
Publicado: (2019)

Mutations in SARS-CoV-2 variant nsp6 enhance type-I interferon antagonism
por: Bills, Cody J., et al.
Publicado: (2023)

YAP accelerates vascular senescence via blocking autophagic flux and activating mTOR
por: Pan, Xianmei, et al.
Publicado: (2020)

hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs
por: Zhang, Xi, et al.
Publicado: (2022)

Enhanced replication fitness of MERS-CoV clade B over clade A strains in camelids explains the dominance of clade B strains in the Arabian Peninsula
por: Te, Nigeer, et al.
Publicado: (2021)

MERS-CoV seroconversion amongst Malaysian Hajj pilgrims returning from the Middle East, 2016–2018: results from the MERCURIAL multiyear prospective cohort study
por: Johari, Jefree, et al.
Publicado: (2023)

mTOR and lysosome regulation
por: Puertollano, Rosa
Publicado: (2014)

Increased mTOR Signaling and Impaired Autophagic Flux Are Hallmarks of SARS-CoV-2 Infection
por: Zambalde, Érika Pereira, et al.
Publicado: (2022)

RORα Enhances Lysosomal Acidification and Autophagic Flux in the Hepatocytes
por: Kim, Hyeon‐Ji, et al.
Publicado: (2021)

Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics
por: Miyazaki, Masaya, et al.
Publicado: (2021)

The Protective Role of TLR2 Mediates Impaired Autophagic Flux by Activating the mTOR Pathway During Neospora caninum Infection in Mice
por: Wang, Jielin, et al.
Publicado: (2021)

The mTOR–lysosome axis at the centre of ageing
por: Carosi, Julian M., et al.
Publicado: (2021)

HLA-Bw4 in association with KIR3DL1 favors natural killer cell-mediated protection against severe COVID-19
por: Wang, Ruihua, et al.
Publicado: (2023)

Docosahexaenoic Acid-Enhanced Autophagic Flux Improves Cardiac Dysfunction after Myocardial Infarction by Targeting the AMPK/mTOR Signaling Pathway
por: Shi, Youyang, et al.
Publicado: (2022)

The Lysosomal Membrane Protein Lamp2 Alleviates Lysosomal Cell Death by Promoting Autophagic Flux in Ischemic Cardiomyocytes
por: Cui, Lin, et al.
Publicado: (2020)

Autophagy termination and lysosome reformation regulated by mTOR
por: Yu, Li, et al.
Publicado: (2010)

cPKCγ-Modulated Sequential Reactivation of mTOR Inhibited Autophagic Flux in Neurons Exposed to Oxygen Glucose Deprivation/Reperfusion
por: Hua, Rongrong, et al.
Publicado: (2018)

Sestrin2 regulates microglia polarization through mTOR-mediated autophagic flux to attenuate inflammation during experimental brain ischemia
por: He, Tingting, et al.
Publicado: (2020)

The phytochemical polydatin ameliorates non‐alcoholic steatohepatitis by restoring lysosomal function and autophagic flux
por: Chen, Xiaoting, et al.
Publicado: (2019)

Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: Implications for hepatotoxicity
por: Jung, Seung-Hwan, et al.
Publicado: (2020)

Activity-independent targeting of mTOR to lysosomes in primary osteoclasts
por: Wang, Andrew, et al.
Publicado: (2017)

Modified 5-aminolevulinic acid photodynamic therapy suppresses cutaneous squamous cell carcinoma through blocking Akt/mTOR-mediated autophagic flux
por: Zeng, Qingyu, et al.
Publicado: (2023)

HBsAg Dampened STING Associated Activation of NK Cells in HBeAg-Negative CHB Patients
por: Zheng, Bingqing, et al.
Publicado: (2021)

Nerve growth factor-induced Akt/mTOR activation protects the ischemic heart via restoring autophagic flux and attenuating ubiquitinated protein accumulation
por: Wang, Zhou-Guang, et al.
Publicado: (2016)

AB77. Tetrandrine blocks autophagic flux by preventing lysosomal acidification in 786-O cells
por: Gong, Yanqing, et al.
Publicado: (2014)

Endoplasmic reticulum stress disrupts lysosomal homeostasis and induces blockade of autophagic flux in human trophoblasts
por: Nakashima, Akitoshi, et al.
Publicado: (2019)

Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction
por: Luo, Li, et al.
Publicado: (2022)

COVID-19: imbalanced cell-mediated immune response drives to immunopathology
por: Wang, Jun, et al.
Publicado: (2022)

Inhibition of autophagic-lysosomal delivery and autophagic lactolysis by asparagine
Publicado: (1991)

ACE2 decoy receptor generated by high-throughput saturation mutagenesis efficiently neutralizes SARS-CoV-2 and its prevalent variants
por: Wang, Bolun, et al.
Publicado: (2022)

Neutralization against Omicron subvariants after BA.5/BF.7 breakthrough infection weakened as virus evolution and aging despite repeated prototype-based vaccination(1)
por: Wang, Hongyu, et al.
Publicado: (2023)

Reduced sensitivity of the SARS-CoV-2 Lambda variant to monoclonal antibodies and neutralizing antibodies induced by infection and vaccination
por: Wang, Meiyu, et al.
Publicado: (2021)

Vaccination effects on post-infection outcomes in the Omicron BA.2 outbreak in Shanghai
por: Wu, Qianhui, et al.
Publicado: (2023)

Iron Promotes Dihydroartemisinin Cytotoxicity via ROS Production and Blockade of Autophagic Flux via Lysosomal Damage in Osteosarcoma
por: Shen, Ying, et al.
Publicado: (2020)

A second functional furin site in the SARS-CoV-2 spike protein
por: Zhang, Yue, et al.
Publicado: (2022)

Iron Oxide Nanoparticle-Induced Autophagic Flux Is Regulated by Interplay between p53-mTOR Axis and Bcl-2 Signaling in Hepatic Cells
por: Uzhytchak, Mariia, et al.
Publicado: (2020)

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
por: Settembre, Carmine, et al.
Publicado: (2012)

Concerns related to the interactions between COVID-19 vaccination and cancer/cancer treatment were barriers to complete primary vaccination series among Chinese cancer patients: A multicentre cross-sectional survey
por: Zhang, Lei, et al.
Publicado: (2023)

Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein
por: Xu, Shiqi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ksgok01519popk6rccqgejs688