Development of 10-Hydroxycamptothecin-crizotinib conjugate based on the synergistic effect on lung cancer cells

The effect of the combination of 10-Hydroxycamptothecin (HCPT) and crizotinib (CRI) on EGFR- and KRAS-mutant lung cancer cells was investigated and the conjugates of the two drugs were synthesised. HCPT combined with CRI synergistically inhibited the cell growth and proliferation of H1975, HCC827, a...

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Detalles Bibliográficos
Autores principales: Liu, Zhen, Xu, Ye, Guo, Lvqian, Li, Xinran, Gao, Junling, Xie, Weiran, Zhao, Lianbo, Teng, Yuou, Li, Xuejiao, Yu, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621280/
https://www.ncbi.nlm.nih.gov/pubmed/36305251
http://dx.doi.org/10.1080/14756366.2022.2132487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621280/
https://www.ncbi.nlm.nih.gov/pubmed/36305251
http://dx.doi.org/10.1080/14756366.2022.2132487

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